ea0037gp.08.02 | Reproduction: Male and endocrine disruptors | ECE2015
Ferlin Alberto
, D'Aurora Marco
, Nicola Marta Di
, Garolla Andrea
, Toni Luca De
, Franchi Sara
, Palka Giandomenico
, Foresta Carlo
, Stuppia Liborio
, Gatta Valentina
Background: Klinefelter syndrome (KS) is the most common abnormality of sex chromosomes (47,XXY) and represents the first genetic cause of male infertility. Mechanisms leading to KS testis degeneration are still not completely defined but considered to be mainly the result of germ cells loss. In order to unravel the molecular basis of global testis dysfunction in KS patients, we performed a transcriptome analysis on testis biopsies obtained from six azoospermic non-mosaic KS p...